Biology

>

A-Level

Biological Molecules

Question

What does it mean if an enzyme is denatured?

2 years ago

·

1 Reply

·

1573 views

M

Marjolaine Ondricka


1 Answer

Jed F Profile Picture
Jed F Verified Sherpa Tutor ✓

Fun, young & creative teacher for sciences with a biology specialism!

8 reviews

Enzymes are proteins that are complicated and specific shapes as determined by the primary sequence of amino acids. This gives rise to

the secondary sequence and subsequently the tertiary structure which is the 3-D structure of the enzyme. A key area of the enzyme is the active site which is where the substrate binds to the enzyme. This active site has a unique 3-D shape specific to the shape of the substrate. The shape of the active site is held together by bonds such as hydrogen bonds and week ionic forces. When an enzyme is denatured by extreme temperatures or pH the bonds within the active site of the enzyme are disrupted and as a result the shape of the active site begins to alter and break down. In increasing temperature, increasing kinetic energy to the bonds leads to the breakdown of the shape of the active site. With pH Hydrogen ion interfere with the charges that are needed to maintain the bonds. As a result the substrate no longer fits into the active site, the reaction cannot be catalysed.

I'm available for 1:1 private online tuition!

Click here to view my profile and arrange a free introduction.

Think you can help?

More Biology A-Level Questions
Sherpa Badge

Need an A-Level Biology tutor?

Get started with a free online introductions with an experienced and qualified online tutor on Sherpa.

Find an A-Level Biology Tutor