How does the character of Madame affect the plot of 'Never Let Me Go'?

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In which ways does the character of Madame enhance the plot of 'Never Let Me Go'? Which point of view does the character of Madame represent in 'Never Let Me Go'? How does the character of Madame affect the plot? How does the character of Madame add to the story development? Give an example of foreshadowing in ‘Never Let Me Go’ and explain how it might affect the portrayal of the character of Madame.